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Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP
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Nuclear Juicer
Created on Mon, 2022-06-27 12:36, last updated on Mon, 2022-06-27 13:03
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General Information
This Model was autogenerated from the
"Quick Submit"
tool.
Model ID
3DPX-017282
Category
Proteins, Macromolecules and Viruses
Keyword(s)
kinase domain, KINASE, ATP binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Protein Data Bank ID
3PP1
Experimental Method
X-RAY DIFFRACTION
Resolution
2.70
Model Details
Associated Species
Escherichia coli
Oligomeric Details
monomeric
R-Factor
0.18379
Scattering Type
x-ray
Attribution
PubMed ID
21 310 613
Digital Object Identifier (DOI)
10.1016/j.bmcl.2011.01.071
Citation Title
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
Journal
Bioorg.Med.Chem.Lett.
Citation Year
2011
STL/VRML Files
PDB-3PP1-ribbon-secondary.wrl
PDB-3PP1-ribbon-rainbow.wrl
PDB-3PP1-ribbon-bychain.wrl
PDB-3PP1-ribbon.stl
PDB-3PP1-surf-bychain.wrl
PDB-3PP1-surf-hydropathy.wrl
PDB-3PP1-surf-coulombic.wrl
PDB-3PP1-surf.stl
PDB-3PP1.zip
X3D Files
PDB-3PP1-ribbon-secondary.x3d
PDB-3PP1-ribbon-rainbow.x3d
PDB-3PP1-ribbon-bychain.x3d
PDB-3PP1-ribbon.x3d
PDB-3PP1-surf-bychain.x3d
PDB-3PP1-surf-hydropathy.x3d
PDB-3PP1-surf-coulombic.x3d
PDB-3PP1-surf.x3d
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