KIT kinase domain mutant D816H in complex with sunitinib

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Millhill

Created on Mon, 2020-12-21 17:01, last updated on Mon, 2020-12-21 17:01

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-015291

Category

Proteins, Macromolecules and Viruses

Keyword(s)

KIT Kinase domain, Sutent binding, drug resistance, ATP-binding, Disease mutation, glycoprotein, Immunoglobulin Domain, KINASE, Membrane, Nucleotide-binding

Protein Data Bank ID

3G0F

Experimental Method

X-RAY DIFFRACTION

Resolution

2.6

Model Details

Associated Species

Spodoptera frugiperda

Oligomeric Details

tetrameric

R-Factor

0.207

Scattering Type

x-ray

Attribution

PubMed ID

19 164 557

Digital Object Identifier (DOI)

10.1073/pnas.0812413106

Citation Title

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.

Citation Year

2009

STL/VRML Files

PDB-3G0F-ribbon-secondary.wrl

PDB-3G0F-ribbon-rainbow.wrl

PDB-3G0F-ribbon-bychain.wrl

PDB-3G0F-ribbon.stl

PDB-3G0F-surf-bychain.wrl

PDB-3G0F-surf-hydropathy.wrl

PDB-3G0F-surf-coulombic.wrl

PDB-3G0F-surf.stl

PDB-3G0F.zip

X3D Files

PDB-3G0F-ribbon-secondary.x3d

PDB-3G0F-ribbon-rainbow.x3d

PDB-3G0F-ribbon-bychain.x3d

PDB-3G0F-ribbon.x3d

PDB-3G0F-surf-bychain.x3d

PDB-3G0F-surf-hydropathy.x3d

PDB-3G0F-surf-coulombic.x3d

PDB-3G0F-surf.x3d

QR Code for https://3dprint.nih.gov/discover/3dpx-015291

KIT kinase domain mutant D816H in complex with sunitinib

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