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Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-5,8-dimethyl-2-naphthonitrile (JLJ658), a Non-nucleoside Inhibitor
Autogenerated by
for
Meghan McCarthy
Created on Wed, 2020-07-22 09:19, last updated on Wed, 2020-07-22 09:19
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General Information
This Model was autogenerated from the
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tool.
Model ID
3DPX-014693
Category
Proteins, Macromolecules and Viruses
Keyword(s)
polymerase, Reverse Transcriptase, NON-NUCLEOSIDE INHIBITOR, TRANSFERASE, HYDROLASE-INHIBITOR complex, HYDROLASE-NHIBITOR complex
Protein Data Bank ID
6X4C
Experimental Method
X-RAY DIFFRACTION
Resolution
2.850
Model Details
Associated Species
Escherichia coli BL21(DE3)
Oligomeric Details
dimeric
R-Factor
0.2220
Scattering Type
x-ray
Attribution
PubMed ID
32 643 196
Digital Object Identifier (DOI)
10.1002/pro.3910
Citation Title
Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to WT and Y181C Reverse Transcriptase Highlights Key Features of the NNRTI Binding Site.
Citation Year
2020
STL/VRML Files
PDB-6X4C-ribbon-secondary.wrl
PDB-6X4C-ribbon-rainbow.wrl
PDB-6X4C-ribbon-bychain.wrl
PDB-6X4C-ribbon.stl
PDB-6X4C-surf-bychain.wrl
PDB-6X4C-surf-hydropathy.wrl
PDB-6X4C-surf-coulombic.wrl
PDB-6X4C-surf.stl
PDB-6X4C.zip
X3D Files
PDB-6X4C-ribbon-secondary.x3d
PDB-6X4C-ribbon-rainbow.x3d
PDB-6X4C-ribbon-bychain.x3d
PDB-6X4C-ribbon.x3d
PDB-6X4C-surf-bychain.x3d
PDB-6X4C-surf-hydropathy.x3d
PDB-6X4C-surf-coulombic.x3d
PDB-6X4C-surf.x3d
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