Skip to main content
U.S. Department of Health and Human Services
—
National Institutes of Health
Create Account
Login
Main menu
Discover
Share
Create
Learn
KRAS G12D in complex with MRTX-1133
Submitted by:
Finlaymaclean
Wed, 2022-10-26 16:20
I Printed This
Remix It
Vertical Tabs
General Information
Model ID
3DPX-017750
Category
Small Molecules
Keyword(s)
ONCOPROTEIN, G12D, GDP, GTPase, KRAS4B, HYDROLASE-HYDROLASE INHIBITOR complex
Experimental Method
X-RAY DIFFRACTION
Resolution
1.3
Resolution Units
Angstroms (A)
Model Details
Associated Species
Escherichia coli
Oligomeric Details
monomeric
R-Factor
0.1499
Scattering Type
x-ray
Attribution
PubMed ID
34 889 605
Digital Object Identifier (DOI)
10.1021/acs.jmedchem.1c01688
Citation Title
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor.
Journal
J.Med.Chem.
Citation Year
2022
STL/VRML Files
PDB-7RPZ-ribbon-secondary.wrl
PDB-7RPZ-ribbon-rainbow.wrl
PDB-7RPZ-ribbon-bychain.wrl
PDB-7RPZ-ribbon.stl
PDB-7RPZ-surf-bychain.wrl
PDB-7RPZ-surf-hydropathy.wrl
PDB-7RPZ-surf-coulombic.wrl
PDB-7RPZ-surf.stl
PDB-7RPZ.zip
X3D Files
PDB-7RPZ-ribbon-secondary.x3d
PDB-7RPZ-ribbon-rainbow.x3d
PDB-7RPZ-ribbon-bychain.x3d
PDB-7RPZ-ribbon.x3d
PDB-7RPZ-surf-bychain.x3d
PDB-7RPZ-surf-hydropathy.x3d
PDB-7RPZ-surf-coulombic.x3d
PDB-7RPZ-surf.x3d
Rating
Select rating
Give KRAS G12D in complex with MRTX-1133 1/5
Give KRAS G12D in complex with MRTX-1133 2/5
Give KRAS G12D in complex with MRTX-1133 3/5
Give KRAS G12D in complex with MRTX-1133 4/5
Give KRAS G12D in complex with MRTX-1133 5/5
Cancel rating
No votes yet
Licensing
Comments
0
