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Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative
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BStromer
Created on Thu, 2021-09-02 13:55, last updated on Thu, 2021-09-02 13:55
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General Information
This Model was autogenerated from the
"Quick Submit"
tool.
Model ID
3DPX-016091
Category
Proteins, Macromolecules and Viruses
Keyword(s)
vegfr2, kinase domain, Tyrosin-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Protein Data Bank ID
3VO3
Experimental Method
X-RAY DIFFRACTION
Resolution
1.520
Model Details
Associated Species
Spodoptera frugiperda
Oligomeric Details
monomeric
R-Factor
0.1619
Scattering Type
x-ray
Attribution
PubMed ID
23 498 918
Digital Object Identifier (DOI)
10.1016/j.bmc.2013.01.074
Citation Title
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Citation Year
2013
STL/VRML Files
PDB-3VO3-ribbon-secondary.wrl
PDB-3VO3-ribbon-rainbow.wrl
PDB-3VO3-ribbon-bychain.wrl
PDB-3VO3-ribbon.stl
PDB-3VO3-surf-bychain.wrl
PDB-3VO3-surf-hydropathy.wrl
PDB-3VO3-surf-coulombic.wrl
PDB-3VO3-surf.stl
PDB-3VO3.zip
X3D Files
PDB-3VO3-ribbon-secondary.x3d
PDB-3VO3-ribbon-rainbow.x3d
PDB-3VO3-ribbon-bychain.x3d
PDB-3VO3-ribbon.x3d
PDB-3VO3-surf-bychain.x3d
PDB-3VO3-surf-hydropathy.x3d
PDB-3VO3-surf-coulombic.x3d
PDB-3VO3-surf.x3d
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