Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative

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BStromer

Created on Thu, 2021-09-02 13:55, last updated on Thu, 2021-09-02 13:55

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-016091

Category

Proteins, Macromolecules and Viruses

Keyword(s)

vegfr2, kinase domain, Tyrosin-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Protein Data Bank ID

3VO3

Experimental Method

X-RAY DIFFRACTION

Resolution

1.520

Model Details

Associated Species

Spodoptera frugiperda

Oligomeric Details

monomeric

R-Factor

0.1619

Scattering Type

x-ray

Attribution

PubMed ID

23 498 918

Digital Object Identifier (DOI)

10.1016/j.bmc.2013.01.074

Citation Title

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Citation Year

2013

STL/VRML Files

PDB-3VO3-ribbon-secondary.wrl

PDB-3VO3-ribbon-rainbow.wrl

PDB-3VO3-ribbon-bychain.wrl

PDB-3VO3-ribbon.stl

PDB-3VO3-surf-bychain.wrl

PDB-3VO3-surf-hydropathy.wrl

PDB-3VO3-surf-coulombic.wrl

PDB-3VO3-surf.stl

PDB-3VO3.zip

X3D Files

PDB-3VO3-ribbon-secondary.x3d

PDB-3VO3-ribbon-rainbow.x3d

PDB-3VO3-ribbon-bychain.x3d

PDB-3VO3-ribbon.x3d

PDB-3VO3-surf-bychain.x3d

PDB-3VO3-surf-hydropathy.x3d

PDB-3VO3-surf-coulombic.x3d

PDB-3VO3-surf.x3d

QR Code for https://3dprint.nih.gov/discover/3dpx-016091

Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative

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