Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy

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benhur974

Created on Tue, 2020-06-02 13:33, last updated on Tue, 2020-06-02 13:33

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-014489

Category

Proteins, Macromolecules and Viruses

Keyword(s)

Serine_protease, INHIBITOR, COMPLEX, HYDROLASE

Protein Data Bank ID

5NX1

Experimental Method

X-RAY DIFFRACTION

Resolution

1.853

Model Details

Associated Species

Trichoplusia ni

Oligomeric Details

tetrameric

R-Factor

0.1860

Scattering Type

x-ray

Attribution

PubMed ID

29 934 309

Digital Object Identifier (DOI)

10.1074/jbc.RA117.000871

Citation Title

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.

Citation Year

2018

STL/VRML Files

PDB-5NX1-ribbon-secondary.wrl

PDB-5NX1-ribbon-rainbow.wrl

PDB-5NX1-ribbon-bychain.wrl

PDB-5NX1-ribbon.stl

PDB-5NX1-surf-bychain.wrl

PDB-5NX1-surf-hydropathy.wrl

PDB-5NX1-surf-coulombic.wrl

PDB-5NX1-surf.stl

PDB-5NX1.zip

X3D Files

PDB-5NX1-ribbon-secondary.x3d

PDB-5NX1-ribbon-rainbow.x3d

PDB-5NX1-ribbon-bychain.x3d

PDB-5NX1-ribbon.x3d

PDB-5NX1-surf-bychain.x3d

PDB-5NX1-surf-hydropathy.x3d

PDB-5NX1-surf-coulombic.x3d

PDB-5NX1-surf.x3d

QR Code for https://3dprint.nih.gov/discover/3dpx-014489

Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy

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