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Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
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benhur974
Created on Tue, 2020-06-02 13:33, last updated on Tue, 2020-06-02 13:33
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3DPX-003358
nevitdilmen
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General Information
This Model was autogenerated from the
"Quick Submit"
tool.
Model ID
3DPX-014489
Category
Proteins, Macromolecules and Viruses
Keyword(s)
Serine_protease, INHIBITOR, COMPLEX, HYDROLASE
Protein Data Bank ID
5NX1
Experimental Method
X-RAY DIFFRACTION
Resolution
1.853
Model Details
Associated Species
Trichoplusia ni
Oligomeric Details
tetrameric
R-Factor
0.1860
Scattering Type
x-ray
Attribution
PubMed ID
29 934 309
Digital Object Identifier (DOI)
10.1074/jbc.RA117.000871
Citation Title
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
Citation Year
2018
STL/VRML Files
PDB-5NX1-ribbon-secondary.wrl
PDB-5NX1-ribbon-rainbow.wrl
PDB-5NX1-ribbon-bychain.wrl
PDB-5NX1-ribbon.stl
PDB-5NX1-surf-bychain.wrl
PDB-5NX1-surf-hydropathy.wrl
PDB-5NX1-surf-coulombic.wrl
PDB-5NX1-surf.stl
PDB-5NX1.zip
X3D Files
PDB-5NX1-ribbon-secondary.x3d
PDB-5NX1-ribbon-rainbow.x3d
PDB-5NX1-ribbon-bychain.x3d
PDB-5NX1-ribbon.x3d
PDB-5NX1-surf-bychain.x3d
PDB-5NX1-surf-hydropathy.x3d
PDB-5NX1-surf-coulombic.x3d
PDB-5NX1-surf.x3d
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