Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36

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bejan3D

Created on Sun, 2020-05-17 22:58, last updated on Sun, 2020-05-17 22:58

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-014367

Category

Proteins, Macromolecules and Viruses

Keyword(s)

receptor tyrosine kinase, INHIBITOR, Crizotinib, NEUROBLASTOMA, CD246, PHOSPHOTRANSFERASE, NPM-ALK, EML4-ALK, TRANSFERASE-INHIBITOR complex

Protein Data Bank ID

4FOD

Experimental Method

X-RAY DIFFRACTION

Resolution

2.00

Model Details

Associated Species

Spodoptera frugiperda

Oligomeric Details

monomeric

R-Factor

0.1796

Scattering Type

x-ray

Attribution

PubMed ID

22 734 674

Digital Object Identifier (DOI)

10.1021/jm3005866

Citation Title

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer.

Citation Year

2012

STL/VRML Files

PDB-4FOD-ribbon-secondary.wrl

PDB-4FOD-ribbon-rainbow.wrl

PDB-4FOD-ribbon-bychain.wrl

PDB-4FOD-ribbon.stl

PDB-4FOD-surf-bychain.wrl

PDB-4FOD-surf-hydropathy.wrl

PDB-4FOD-surf-coulombic.wrl

PDB-4FOD-surf.stl

PDB-4FOD.zip

X3D Files

PDB-4FOD-ribbon-secondary.x3d

PDB-4FOD-ribbon-rainbow.x3d

PDB-4FOD-ribbon-bychain.x3d

PDB-4FOD-ribbon.x3d

PDB-4FOD-surf-bychain.x3d

PDB-4FOD-surf-hydropathy.x3d

PDB-4FOD-surf-coulombic.x3d

PDB-4FOD-surf.x3d

QR Code for https://3dprint.nih.gov/discover/3dpx-014367

Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36

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