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Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
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b.dickson
Created on Sun, 2019-12-01 17:47, last updated on Sun, 2019-12-01 17:47
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General Information
This Model was autogenerated from the
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tool.
Model ID
3DPX-012614
Category
Proteins, Macromolecules and Viruses
Protein Data Bank ID
4OQA
Keyword(s)
Zinc Finger
DNA binding
PARP
polymerase
DNA repair
poly(adp-ribosyl)ation
TRANSFERASE-DNA-TRANSFERASE INHIBITOR complex
Model Details
Experimental Method
X-RAY DIFFRACTION
Associated Species
Escherichia coli
Resolution
3.65
Oligomeric Details
tetrameric
R-Factor
0.30022
Scattering Type
x-ray
Attribution
PubMed ID
24 922 587
Digital Object Identifier (DOI)
10.1021/jm5002502
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
Citation Year
2014
STL/VRML Files
PDB-4OQA-ribbon-secondary.wrl
PDB-4OQA-ribbon-rainbow.wrl
PDB-4OQA-ribbon-bychain.wrl
PDB-4OQA-ribbon.stl
PDB-4OQA-surf-bychain.wrl
PDB-4OQA-surf-hydropathy.wrl
PDB-4OQA-surf-coulombic.wrl
PDB-4OQA-surf.stl
PDB-4OQA.zip
X3D Files
PDB-4OQA-ribbon-secondary.x3d
PDB-4OQA-ribbon-rainbow.x3d
PDB-4OQA-ribbon-bychain.x3d
PDB-4OQA-ribbon.x3d
PDB-4OQA-surf-bychain.x3d
PDB-4OQA-surf-hydropathy.x3d
PDB-4OQA-surf-coulombic.x3d
PDB-4OQA-surf.x3d
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Give Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 1/5
Give Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 2/5
Give Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 3/5
Give Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 4/5
Give Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 5/5
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