Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide

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b.dickson

Created on Sun, 2019-12-01 17:47, last updated on Sun, 2019-12-01 17:47

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-012614

Category

Proteins, Macromolecules and Viruses

Keyword(s)

Zinc Finger, DNA binding, PARP, polymerase, DNA repair, poly(adp-ribosyl)ation, TRANSFERASE-DNA-TRANSFERASE INHIBITOR complex

Protein Data Bank ID

4OQA

Model Details

Experimental Method

X-RAY DIFFRACTION

Associated Species

Escherichia coli

Resolution

3.65

Oligomeric Details

tetrameric

R-Factor

0.30022

Scattering Type

x-ray

Attribution

PubMed ID

24 922 587

Digital Object Identifier (DOI)

10.1021/jm5002502

Citation Title

Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.

Citation Year

2014