Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor

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mariahong

Created on Fri, 2016-11-25 17:19, last updated on Fri, 2016-11-25 17:19

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID 

3DPX-004214

Category 

Proteins, Macromolecules and Viruses

Keyword(s) 

FATTY ACID SYNTHASE, INHIBITOR, beta-ketoacyl reductase, cancer, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

Protein Data Bank ID 

5C37

Experimental Method 

X-RAY DIFFRACTION

Resolution 

2.300

Model Details

Associated Species 

Spodoptera frugiperda

Oligomeric Details 

monomeric

R-Factor 

0.2112

Scattering Type 

x-ray

Attribution

Citation Title 

Design and Synthesis of a Series of Bioavailable Fatty Acid Synthase (FASN) KR Domain Inhibitors for Cancer Therapy

STL/VRML Files

 

PDB-5C37-ribbon-secondary.wrl

PDB-5C37-ribbon-rainbow.wrl

PDB-5C37-ribbon-bychain.wrl

PDB-5C37-ribbon.stl

PDB-5C37-surf-bychain.wrl

PDB-5C37-surf-hydropathy.wrl

PDB-5C37-surf-coulombic.wrl

PDB-5C37-surf.stl

PDB-5C37.zip

X3D Files

 

PDB-5C37-ribbon-secondary.x3d

PDB-5C37-ribbon-rainbow.x3d

PDB-5C37-ribbon-bychain.x3d

PDB-5C37-ribbon.x3d

PDB-5C37-surf-bychain.x3d

PDB-5C37-surf-hydropathy.x3d

PDB-5C37-surf-coulombic.x3d

PDB-5C37-surf.x3d

Blender Files

 

PDB-5C37-ribbon-secondary.blend

PDB-5C37-ribbon-rainbow.blend

PDB-5C37-ribbon-bychain.blend

PDB-5C37-ribbon.blend

PDB-5C37-surf-bychain.blend

PDB-5C37-surf-hydropathy.blend

PDB-5C37-surf-coulombic.blend

PDB-5C37-surf.blend

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