U.S. Department of Health and Human Services — National Institutes of Health

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

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Created on Thu, 2015-03-05 21:37, last updated on Tue, 2022-05-17 14:41

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General Information

This Model was autogenerated from the "Quick Submit" tool.

Model ID

3DPX-001132

Category

Proteins, Macromolecules and Viruses

Keyword(s)

COMPLEX (ISOMERASE-DNA), DNA, TOPOISOMERASE I, drug, poison, ISOMERASE-DNA complex

Protein Data Bank ID

1K4T

Experimental Method

X-RAY DIFFRACTION

Resolution

2.10

Model Details

Associated Species

Spodoptera frugiperda

Oligomeric Details

tetrameric

Scattering Type

x-ray

Attribution

PubMed ID

12 426 403

Digital Object Identifier (DOI)

10.1073/pnas.242259599

Citation Title

The mechanism of topoisomerase I poisoning by a camptothecin analog

Citation Year

2002

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

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