Image Credit: David Goodsell

PDB-101: Molecule of the Month

Created by David Goodsell and the RCSB Protein Data Bank

The RCSB PDB Molecule of the Month by David S. Goodsell (The Scripps Research Institute and the RCSB PDB) presents short accounts on selected molecules from the Protein Data Bank. Each installment includes an introduction to the structure and function of the molecule, a discussion of the relevance of the molecule to human health and welfare, and suggestions for how visitors might view these structures and access further details.

This feature provides an easy introduction to the RCSB PDB for all types of users, but especially for teachers and students. It is used in many classrooms to introduce structures to students, and is an integral part of the protein modeling event at the Science Olympiad. It is not intended to be a comprehensive index to entries in the PDB archive, nor necessarily represent the historical record. The structures used to illustrate each installment are chosen at the discretion of the authors. Goodsell described the creation of these articles and images in an interview with the RCSB PDB Newsletter.

This 3DPX collection aims to bring together 3D-printable models of PDB entries discussed in the Molecule of the Month series. This collection is currently incomplete, as we are working to upload all the individual models to the site, with info and links relevant to their respective Molecule of the Month article.

July 2015: New Delhi Metallo-β-Lactamase

June 2015: Receptor for Advanced Glycation End Products

May 2015: Titin

April 2015: Glucagon

March 2015: Phototropin

February 2015: Insulin Receptor

January 2015: Cascade and CRISPR

December 2014: TAL Effectors

November 2014: Methyl-coenzyme M Reductase

October 2014: Ebola Virus Proteins

September 2014: Apoptosome

July 2014: Microtubules

June 2014: GFP-like proteins

May 2014: Aquaporin

April 2014: RecA and Rad51

March 2014: Neurotransmitter Transporters

3DPX-000968 Proteins, Macromolecules and Viruses PDB Molecule of the Month Transporter

February 2014: Broadly Neutralizing Antibodies

January 2014: HIV Envelope Glycoprotein

3DPX-000971 Proteins, Macromolecules and Viruses PDB Molecule of the Month GP41

December 2013: DNA Helicase

November 2013: SNARE Proteins

September 2013: Designed Protein Cages

August 2013: Serotonin Receptor

July 2013: HIV Capsid

June 2013: Dermicidin

May 2013: Ricin

April 2013: Actinomycin

February 2013: Helicobacter pylori, stomach ulcer, urease

January 2013: Transfer-Messenger RNA

December 2012: ABO Blood Group Glycosyltransferases

November 2012: Vitamin D Receptor

October 2012: Citric Acid Cycle

July 2012: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

June 2012: Sliding Clamps

May 2012: Leptin

April 2012: Ras Protein

March 2012: Rhodopsin

January 2012: Messenger RNA Capping

November 2011: Toll-like Receptors

October 2011: PDB Pioneers

September 2011: O-GlcNAc Transferase

July 2008: Dengue virus capsid

October 2006: Cytochrome p450

September 2004: Catalase

January 2004: Carbonic Anhydrase

June 2003: Green Fluorescent Protein (GFP)

May 2003: Hemoglobin

November 2002: Ferritin and Transferrin

January 2001: Alcohol Dehydrogenase

October 2000: Ribosomal Subunits

September 2000: Lysozyme

April 2000: Collagen